Juvenile Rats - 948 Words

The hypothesize that females are protected from developing neurodevelopmental disorders. That is because of their sex hormones, estrogen provides a great neuroprotection, done by suppressing the neuro-excitotoxicity induced by glutamate. Research article by Etidal Al-Suwailem, Sex differences in the glutamate signaling pathway in juvenile rats goes into the discussion and understanding of how sex gender is represented in autism. The authors conducted research in this area to understand why the female is at lower risk than a male when it comes to the development of neurodevelopmental disorders. With the attempt to understand the differences in glutamate signaling as an etiological mechanism in autism. This research was performed with 15†¦show more content†¦Also, Glu/GABA and Glu/Glt 1 ratios were lower in the female rat than in the male. GLN/GS ratio was also low in females (p=0.021) than in male. What had become an outlier making the researchers see something different wa s when the GLN/GAD =67 was higher in the female rat than in the male. Though GLN was not different in neither the concentration of GS in the brain cells went up by p = 0.019 in the female compared to the male. Even though that was shown higher it didn’t change the hypothesis keeping it still that the female rats will show less effectiveness to obtain the characteristic to obtain neurological development of autism as fast as the male rat. Throughout the experiment though finding the things that support their hypothesis the researchers also came to several others. The researchers came to an understanding that Gln is not active with in the sense it cannot activate the receptors in Glu. This was brought up because of Glu and Gln being enzymes of GS which is found to be very active within the brain especially in the neurons. Sex hormones play such a big role in the process of growing from a juvenile to an adult. With that said estrogen plays a major role along with progesterone as they are ovarian hormones and they begin to start the development within the brain and continue throughout a persons life. That is something I did not know and it is very interesting because some studies show that the brain gets fullyShow MoreRelatedUnderstanding Stress During Puberty937 Words   |  4 Pages In this experiment, the author’s focused on understanding stress during puberty and the sex-specific differences of the effects on humans through rat models. As we go through puberty, both male and females have increased levels of sex steroid hormones. In females this causes levels of cortisol to increase, as well as the probability of developing a mood disorder relating to stress. 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